Pharmacokinetics and Dosimetry of 111In/188Re-Labeled PEGylated Liposomal Drugs in Two Colon Carcinoma-Bearing Mouse Models
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منابع مشابه
Pharmacokinetics, Biodistribution and Bioavailability of Liposomal Drugs
Stealth liposomal doxorubicin (Doxil ® /Caelyx ®) passively targets to tumors through the enhanced permeability and retention (EPR) effect, which is a result of enhanced vascular permeability of tumor blood vessels. The endothelial lining of the diseased site contains gaps that can range from 380-780 nm which are large enough for the extravasation of liposomes (~100 nm). Once the liposomes are ...
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Effects of multiple injections of liposomal doxorubicin on pharmacokinetics, therapeutic outcome, and toxicity were studied in mice using different dosing schedules and dose intensities. Biodistribution of doxorubicin to the cutaneous tissues of mice (skin and paws) and to orthotopically implanted mammary tumors (4T1) was examined. Weekly intravenous administration of pegylated (STEALTH) liposo...
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Brain cancer is a devastating disease affecting many people worldwide. Effective treatment with chemotherapeutics is limited due to the presence of the blood-brain barrier (BBB) that tightly regulates the diffusion of endogenous molecules but also xenobiotics. Glutathione pegylated liposomal doxorubicin (2B3-101) is being developed as a new treatment option for patients with brain cancer. It is...
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PURPOSE PEGylated liposomes are important drug carriers that can passively target tumor by enhanced permeability and retention (EPR) effect in neoplasm lesions. This study demonstrated that tumor burden determines the tumor uptake, and also the tumor response, in cancer treatment with PEGylated liposomal drugs in a C26/tk-luc colon carcinoma-bearing mouse model. METHODS Empty PEGylated liposo...
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ژورنال
عنوان ژورنال: Cancer Biotherapy and Radiopharmaceuticals
سال: 2011
ISSN: 1084-9785,1557-8852
DOI: 10.1089/cbr.2010.0906